The Promise of Folate Receptor Alpha-Targeting ADCs for Platinum-Resistant Ovarian Cancer

Faculty

Kathleen N. Moore, MD, MS, FASCO
Moderator
Deputy Director, Stephenson Cancer Center
Virginia Kerley Cade Chair in Developmental Therapeutics
Professor, Division of Gynecologic Oncology
University of Oklahoma Health Sciences Center
Oklahoma City, OK
Elizabeth (Betsy) Lee, MD
Instructor of Medicine
Department of Medical Oncology, Division of Gynecologic Oncology
Center for Cancer Therapeutic Innovation
Dana-Farber Cancer Institute
Boston, MA

Statement of Need

Ovarian cancer typically responds well to initial platinum-based chemotherapy treatment. However, most tumors subsequently relapse and eventually become resistant, for which the prognosis is poor and no therapeutic options which have shown substantial OS benefit. Further, the available chemotherapies are associated with significant adverse effects that negatively impact quality of life for the patient. Emerging therapies with novel mechanisms of action and adverse effect profiles, such as folate receptor alpha-targeting antibody-drug conjugates (FRα ADCs), will be required for effective management of platinum-resistant ovarian cancer.  


In this CE Concepts Snack, expert faculty will address critical gaps in clinician knowledge and competence by equipping learners with strategies to categorize treatment options and optimize patient-specific care plans incorporating novel therapies. Faculty will also explore approaches to mitigating disparities in ovarian cancer care, ensuring learners can implement equitable, evidence-based practices that enhance patient outcomes. 

Learning Objectives

At the conclusion of this activity, learners will be able to better:

  • Categorize the treatment options for platinum-resistant ovarian cancer based on guidelines and standards of practice
  • Formulate treatment plans for patients with platinum-resistant ovarian cancer that appropriately incorporate novel and emerging FRα ADC therapies as they become available
  • Integrate clinical best practices that reduce inequitable ovarian cancer care

Financial Support

This activity is supported by an independent educational grant from Genmab US, Inc.

Target Audience

Medical oncologists, gynecologic oncologists, gynecologists, physician associates (PAs), nurse practitioners (NPs), nurses, pharmacists, and other clinicians who care for patients with ovarian cancer 

Credit Information

Jointly Accredited Provider

In support of improving patient care, Creative Educational Concepts, LLC, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

Physicians (ACCME)

Creative Educational Concepts, LLC, designates this enduring material for a maximum of 1.00 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Accreditation Council for Pharmacy Education

This application-based activity is approved for 1.00 contact hours (0.1 CEUs) of continuing pharmacy credit (JA0007101-0000-25-002-H01-P).

American Nurses Credentialing Center

This activity is designated for 1.00 contact hours.

Note to Nurse Practitioners: The content of this CNE activity pertains to Pharmacology.

American Nurses Credentialing Center with ILNA

This activity is designated for 1.00 contact hours.

The program content has been reviewed by the Oncology Nursing Certification Corporation (ONCC) and is acceptable for recertification points in the following ILNA subject areas:

 

OCN®
​​Care Continuum
​Oncology Nursing Practice
​Treatment

CBCN®
​Care Continuum
​Treatment

CPHON®
​​Care Continuum
​​Treatment

AOCNP®
​​Care Continuum
​​Professional Practice/Performance
​​Roles of the APRN
​​Treatment

BMTCN®
​Professional Practice/Performance

Physician Assistants (AAPA)

Creative Educational Concepts, LLC, has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1.00 AAPA Category 1 CME credits. Approval is valid until 03/17/2026. PAs should only claim credit commensurate with the extent of their participation.

ABIM MOC

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

MIPS Improvement Activity

Completion of this accredited CME activity meets the expectations of an Accredited Safety or Quality Improvement Program (IA_PSPA_28) for the Merit-based Incentive Payment Program (MIPS). Clinicians should submit their improvement activities by attestation via the CMS Quality Payment Program website.

Royal College MOC

Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.

Disclosure Declaration

It is the policy of CE Concepts, LLC, to ensure independence, balance, objectivity, and scientific rigor and integrity in all of their CME/CE activities. Faculty must disclose to the participants any relationships with commercial companies whose products or devices may be mentioned in faculty presentations, or with the commercial supporter of this CME/CE activity. CE Concepts, LLC, has evaluated, identified, and attempted to resolve any potential conflicts of interest through a rigorous content validation procedure, use of evidence-based data/research, and a multidisciplinary peer review process. Relevant financial relationships exist between the following individuals and commercial interests:

Dr. Moore reports the following financial relationships:

Advisory Board: Aadi Bioscience; AbbVie Inc.; AstraZeneca; Caris Life Sciences; Corcept Therapeutics; Daiichi Sankyo; Duality Biologics; BioNTech SE; Eisai Inc.; Genmab; Genentech, Inc./Roche; GSK; ImmunoGen, Inc.; Janssen Pharmaceuticals, Inc.; Merck & Co., Inc.; Mersana Therapeutics; Novartis Pharmaceuticals Corporation; Regeneron Pharmaceuticals, Inc.; Sanofi; Schrodinger, Inc.; Takeda Pharmaceuticals U.S.A., Inc.; Verastem; and Zentalis

Consultant: AstraZeneca; Genmab; and GSK

Research Support: GSK; Lilly; Merck & Co., Inc; and PTC Therapeutics

Other financial or material support: Associate Director, GOG Partners

Dr. Lee reports the following financial relationships:

Advisory Board: Oncusp Therapeutics and ProfoundBio, Inc./Genmab

Research Support: Research funding paid to the institution:  KSQ Therapeutics, Inc./Roche; Merck & Co., Inc.; OnCusp Therapeutics; ProfoundBio, Inc./Genmab; Repare Therapeutics; and Seagen

The following individuals have no financial relationships to disclose: 

Alaa Bawaneh, MD, PhD (Peer Reviewer)
Jessica Giddens, DNP, APRN, FPMHNP-BC, RN-BC (Peer Reviewer)
Thomas Mitchell, MSW (Planning Committee)
David Modrak, PhD (Planning Committee)
Scott J. Hershman, MD, FACEHP, CHCP (Planning Committee)
Sandra Caballero, PharmD (Planning Committee)
Sharon Tordoff (Planning Committee)

*All identified conflicts of interest have been mitigated.

Unlabeled Use Disclosure
Faculty of this CME/CE activity may include discussions of products or devices that are not currently labeled for use by the FDA. The faculty have been informed of their responsibility to disclose to the audience if they will be discussing off-label or investigational uses (any uses not approved by the FDA) of products or devices. CE Concepts, LLC, the faculty, planners, and reviewers do not endorse the use of any product outside of the FDA labeled indications. Medical professionals should not utilize the procedures, products, or diagnosis techniques discussed during this activity without evaluation of their patient for contraindications or dangers of use.

Obtaining Credit

Post-tests, credit request forms, and activity evaluations must be completed online (requires free account activation), and participants can print their certificate or statement of credit immediately (75% pass rate required). This website supports all browsers except Internet Explorer for Mac.

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Questions about this activity?

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SN-252-031725-88

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The Promise of Folate Receptor Alpha-Targeting ADCs for Platinum-Resistant Ovarian Cancer
Activity Date: 03/17/2025