Advancements in the Management of Relapsed/Refractory B-Cell Malignancies – Integrating Recent Data into Practice to Improve Outcomes

Faculty

Matthew S. Davids, MD, MMSc
Associate Professor of Medicine
Harvard Medical School
Leader of Lymphoma Program
Dana-Farber/Harvard Cancer Center
Director of Clinical Research, Division of Lymphoma
Dana-Farber Cancer Institute
Boston, MA

Statement of Need

Despite advancements in the treatment of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and mantle cell lymphoma (MCL), resistance and recurrence occur frequently and mutations might develop during treatment. Given the diverse range of treatment side effects, it is critical that hematology/oncology clinicians know how to select appropriate medications for each patient as well as have insight about optimization of drug sequencing, used alone or in combination, and the issue of intolerance. Clinicians must possess a comprehensive understanding of these challenges and implement specific management of drug-related toxicities using a shared decision-making and multidisciplinary approach.

In this CE Concepts Grand Rounds series, expert faculty will explore the latest clinical trial data on novel treatment options for patients with resistant/recurrent (R/R) CLL/SLL, utilization of an evidence-based approach for personalizing treatment for patients with R/R MCL, and prioritization of patient adherence and active engagement through development of multidisciplinary frameworks to oversee and address adverse events. The faculty will also provide insight through case-based discussions.

Learning Objectives

At the conclusion of this activity, learners will be able to better:

  • Implement novel treatment options for patients with R/R CLL/SLL based on the latest clinical trial data
  • Utilize an evidence-based approach for personalizing treatment for patients with R/R MCL
  • Develop team-based frameworks to oversee and address AEs, prioritizing patient adherence and active engagement

Financial Support

This activity is supported by an independent educational grant from Lilly.

Target Audience

Academic and community hematologists/oncologists, nurse practitioners (NPs), physician associates (PAs), nurses, and pharmacists

Credit Information

Jointly Accredited Provider

In support of improving patient care, Creative Educational Concepts, LLC, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

Physicians (ACCME)

Creative Educational Concepts, LLC, designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Accreditation Council for Pharmacy Education

This application-based activity is approved for 1.00 contact hours (0.1 CEUs) of continuing pharmacy credit (JA0007101-0000-24-018-L01-P).

American Nurses Credentialing Center

This activity is designated for 1.00 contact hours.

Note to Nurse Practitioners: The content of this CNE activity pertains to Pharmacology

American Nurses Credentialing Center with ILNA

This activity is designated for 1.00 contact hours.

The program content has been reviewed by the Oncology Nursing Certification Corporation (ONCC) and is acceptable for recertification points in the following ILNA subject areas:

OCN®

  • ​​Care Continuum
  • ​Oncologic Emergencies
  • ​​Oncology Nursing Practice
  • ​​Psychosocial Dimensions of Care
  • ​​Symptom Management, Palliative Care, Supportive Care
  • ​​Treatment

 

CBCN®

  • ​Care Continuum
  • ​​Psychosocial Dimensions of Care
  • ​​Treatment

 

CPHON®

  • ​​Care Continuum
  • ​​Oncologic Emergencies
  • ​​Oncology Nursing Practice
  • ​​Psychosocial Dimensions of Care
  • ​​Symptom Management, Palliative Care, Supportive Care
  • ​​Treatment

 

AOCNP*

  • Care Continuum
  • Oncologic Emergencies
  • ​Professional Practice/Performance
  • ​Psychosocial Dimensions of Care
  • ​​Symptom Management, Palliative Care, Supportive Care
  • ​​Treatment

 

BMTCN®

  • ​Cellular Collection, Preparative Regimens, and Infusion
  • ​​Foundations of Transplant
  • ​​Professional Practice/Performance
  • ​Quality of Life

Interprofessional Continuing Education

This activity was planned by and for the healthcare team, and learners will receive 1.00 Interprofessional Continuing Education Credit for learning and change.

ABIM MOC

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

MIPS Improvement Activity

Completion of this accredited CME activity meets the expectations of an Accredited Safety or Quality Improvement Program (IA_PSPA_28) for the Merit-based Incentive Payment Program (MIPS). Clinicians should submit their improvement activities by attestation via the CMS Quality Payment Program website.

Royal College MOC

Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.

Disclosure Declaration

Faculty

Dr. Davids reports the following financial relationships:

Consultant: AbbVie Inc.; Adaptive Biotechnologies; Ascentage Pharma; AstraZeneca; BeiGene; Bristol Meyers Squibb; Galapagos; Genentech, Inc.; Genmab; Janssen Pharmaceuticals, Inc.; Lilly; MEI Pharma, Inc.; Merck & Co., Inc.; Nuvalent; Secura Bio; Takeda Pharmaceutical Company Limited; and TG Therapeutics, Inc.

Research Support:
Ascentage Pharma; MEI Pharma, Inc.; and Novartis

Other financial or material support:
UpToDate – royalties

Planner

Ms. Goodrich  reports the following financial relationships:

Advisory Board: AbbVie Inc.; AstraZeneca; BeiGene; Epizyme, Inc.; Genentech, Inc.; and Janssen Pharmaceuticals, Inc.

The following individuals have no financial relationships to disclose: 

Alaa Bawaneh, MD, PhD (Peer Reviewer)
Albert Eubanks, Jr., RN (Peer Reviewer)
Susan Perry (Planning Committee)
David Modrak, PhD (Planning Committee)
Scott J. Hershman, MD, FACEHP, CHCP (Planning Committee)
Sandra Caballero, PharmD (Planning Committee)
Sharon Tordoff (Planning Committee)

Obtaining Credit

Post-tests, credit request forms, and activity evaluations must be completed online (requires free account activation), and participants can print their certificate or statement of credit immediately (75% pass rate required). This website supports all browsers except Internet Explorer for Mac.

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Questions about this activity?

Call us at 859-260-1717  •  info@ceconcepts.com

GR-069

Call us at 859-260-1717  •  info@ceconcepts.com

Advancements in the Management of Relapsed/Refractory B-Cell Malignancies – Integrating Recent Data into Practice to Improve Outcomes
Activity Date: 02/10/2025 at 12:00 PM EST